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Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email. Volume , Issue Previous Article Next Article. View Metrics. Nationwide survey of hemophagocytic lymphohistiocytosis in Japan. Int J Hematol ; Hepatic manifestations of hemophagocytic syndrome: a study of 30 cases.
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Hemophagocytic lymphohistiocytosis. Report of children from the International Registry. Leukemia ; Successful correction of hemophagocytic lymphohistiocytosis with related or unrelated bone marrow transplantation. But in adults, many conditions can cause HLH. This is called acquired HLH. It can be caused by some infections, cancer, and autoimmune diseases. If you have acquired HLH, your body's immune system does not work normally.
Some white blood cells called histiocytes and lymphocytes attack your other blood cells. Abnormal blood cells then build up in your spleen and liver. This causes your spleen and liver to enlarge.
HLH is a life-threatening condition. It can cause death in weeks or months if not treated. It may also cause death in months despite treatment. HLH is a rare disease, and researchers are still learning what causes it. There are 2 types of HLH: familial and acquired.
Familial HLH is passed from parents to children. Acquired HLH in adults can be caused by:. Nervous system problems such as headaches, trouble walking, vision disturbances, and weakness. The symptoms of acquired HLH can look like other health conditions. See your healthcare provider for a diagnosis.
Familial-type HLH is usually fatal if not treated. Treatment for familial or persistent acquired HLH may include:. If drug treatments do not work, your healthcare providers may do a stem cell transplant.
In this procedure, healthy bone marrow cells from a donor replace your diseased bone marrow cells. Stem cell transplant can cure HLH in most cases. There is no way to prevent HLH, but as healthcare providers continue to learn more about it, treatment improves. Most children who are successfully treated go on to live normal lives. Healthcare providers do not regularly do genetic testing for HLH on newborns, because the disease is very rare.
Experts recommend genetic testing for these infants.
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